Cubicin (daptomycin for injection)
Audience: Infectious disease healthcare professionals, hospital risk managers, and nursing service managers

[Posted 04/09/2008] Cubist Pharmaceuticals, Inc. informed  healthcare professionals that a potentially significant impurity,  2-mercaptobenzothiazole (MBT), has been isolated from reconstituted Cubicin  stored in with ReadyMED elastomeric infusion pumps manufactured by Cardinal  Health, Inc. MBT is used in the manufacture of rubber and has been reported to  leach from rubber stoppers and syringe components into medicinal products in  the past. Cutaneous exposure to MBT has been associated with dermal  sensitization, and chronic administration of MBT to laboratory rodents has  been associated with an increased risk of certain tumors. No MBT has been  identified in reconstituted Cubicin in other standard types of infusion  systems that have been tested. Healthcare professionals are advised to  discontinue using ReadyMED elastomeric infusion pumps with Cubicin until the  issue has been addressed.

[April, 2008 - Letter - Cubist Pharmaceuticals, Inc.]

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Unretrieved Device Fragments
Audience: Radiologists, surgeons, hospital risk managers, other healthcare professionals